Endocrine Abstracts

Introduction: Intrauterine growth is a biological process regulated by maternal, placental, and foetal endocrine signals. Birth weight is an indicator of the health of the newborn. Alterations in foetal growth lead to perinatal health risks and favour metabolic diseases during adult life. Therefore, the study of endocrine factors determining birth weight, such as ghrelin is an important issue. Ghrelin may exist as two molecular forms, desacyl ghrelin (DAG) and acyl ghrelin (AG...

Diabetes is associated with a greatly increased risk of cardiovascular disease and the advanced glycation end products (AGEs) and their receptors play an important role in these complications.Objective: To study the association between AGEs and sRAGE levels with cardiovascular risk factors in obese and non-obese newly diagnosed type 2 diabetic patients.Material and methods: We conducted a cross-sectional study in subjects with type...

In obesity the combined effects of enhanced food consumption, enhanced oxidative stress and inflammation could increase levels of advanced glycation end products (AGEs) and the action of their receptors.Objective: To study circulating levels of AGEs, soluble RAGE and AGER-1 and their association with insulin resistance and inflammation in young subjects with obesity and normal weight.Material and methods: We conducted a cross-secti...

Background: Birth weight is a marker and predictor of metabolic diseases in adult life. Fetal growth depends on the availability of nutrients, in turn cross the placental barrier by means of special cells called syncytiotrophoblasts, which express specific transporters for each type of nutrient. Glucose, the main energetic substrate for fetal development, is transported via facilitated diffusion, through glucose transporter proteins (GLUTs). Several investigations have focused...